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Sr. Staff Scientist - Protein Sciences R&D

Twist Bioscience
Location
USA - South San Francisco, CA
Posted
23 days ago
Department
Research & Development
What they actually want (must-haves)
  • PhD in Cell Biology, Biochemistry, or a closely related field
  • 8+ years of experience in protein sciences
  • Deep hands-on experience designing, expressing, and optimizing monoclonal antibodies
  • Proven experience with bispecific antibody architectures
  • Hands-on experience with antibody characterization methods
  • Demonstrated ability to build, improve, and standardize antibody generation workflows
Nice to have
  • Strong understanding of transient vs stable expression tradeoffs
  • Experience improving expression yields and product quality through sequence, vector, and host engineering
  • Experience developing high-throughput or semi-automated workflows
  • Strong understanding of platform robustness, reproducibility, and cost drivers
  • Experience generating and optimizing stable mammalian cell lines
What the job really is

The Sr. Staff Scientist in Protein Sciences R&D will lead the development and enhancement of antibody production workflows, focusing on various formats and purification methods. This role involves both hands-on experimentation and team leadership, requiring the candidate to design and execute experiments while managing a growing team. The position emphasizes a strong technical background in antibody biology and the ability to innovate and improve existing workflows.

Benefits
  • Base salary range of $180,000 — $232,000 USD
  • Eligible for bonus and equity
  • Generous benefits package
Things to weigh
  • Travel 10% of the time to Portland, OR
  • No specific mention of remote work options or flexibility
  • Compensation may vary based on multiple factors, including location
  • Experience with liquid-handling systems and automation is a plus but not required
Job score3.2/5
Benefits2/5
Freshness4/5
Career value5/5
Role clarity5/5
Pay transparency0/5

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