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Principal Scientist, LNP Platform & Process Development

Tr1X
Location
San Diego, CA
Posted
23 days ago
Department
Technical Operations
Salary
$169,000 - $185,000
What they actually want (must-haves)
  • Ph.D. in Chemical Engineering, Bioengineering, Pharmaceutical Sciences, Chemistry, or a related field with a minimum of 6 years of relevant industry experience; or M.S. with 10+ years; or B.S. with 12+ years
  • Demonstrated in-depth expertise in LNP formulation and process development
  • Hands-on experience with microfluidic or scalable mixing technologies and downstream purification strategies such as TFF
  • Strong experience with analytical characterization of tLNP systems and application of statistical design tools for process optimization
  • Experience with mRNA therapeutics or nucleic acid delivery systems
  • Experience with conjugation of targeting ligands to lipid nanoparticles
Nice to have
  • Prior exposure to immunotherapy or in-vivo cell therapy platforms
  • Experience correlating formulation attributes with in vivo performance (mouse, NHP)
  • Experience with mRNA production and analytical quality control
What the job really is

The Principal Scientist, LNP Platform & Process Development at Tr1X will lead the design and optimization of lipid nanoparticle (LNP) formulations for mRNA delivery, playing a crucial role in the development of the company's CAR-Treg platform. This hands-on position involves evaluating lipid compositions, developing production processes, and collaborating with biology teams to support in vitro and in vivo studies, all while contributing to IND-enabling documentation and long-term strategy for LNP platform development.

Benefits
  • Base salary
  • Discretionary annual target bonus
  • Incentive stock options
  • 401(k) retirement plan with company contribution
  • Health and welfare insurance plans including medical, dental, vision, long-term and short-term disability, and life insurance
  • Paid time off (PTO)
Things to weigh
  • Position is on-site in San Diego, which may limit remote work options
  • Travel may be required up to 10% of the time
  • No specific mention of career advancement opportunities or professional development programs
Job score4.4/5
Benefits4/5
Freshness4/5
Career value4/5
Role clarity5/5
Pay transparency5/5

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