HHiring Reality
← Profluent

Scientist II - Sr. Scientist, CRISPR Specificity & Genomic Safety

Profluent
Location
Emeryville, California, United States; On-site
Posted
2 months ago
Department
Biology
What they actually want (must-haves)
  • PhD (or equivalent) in molecular biology, genomics, genome editing, biochemistry, bioengineering, genetics, chemical biology, or a related field
  • 2-4 years of relevant industry experience in genome editing specificity and genomic safety assessment
  • Deep expertise and hands-on experience with CRISPR-based genome editing systems, particularly base editors
  • Hands-on experience developing, optimizing, or applying NGS-based workflows for genome editing analysis
  • Strong experimental background in molecular biology, mammalian cell culture, genome editing reagent delivery, NGS library preparation, assay troubleshooting, and quantitative analysis of editing outcomes
  • Experience interpreting complex sequencing datasets and collaborating with bioinformatics or computational biology teams
Nice to have
  • Experience with therapeutic genome editing programs and genomic safety packages for candidate nomination, IND-enabling studies, or regulatory-facing documentation
  • Experience working with disease-relevant primary cells, ex vivo edited cells, iPSC-derived systems, or other therapeutically relevant model systems
  • Familiarity with ML-guided enzyme engineering campaigns
  • Expertise in protein purification of genome editors for use in biochemical off-target assays
What the job really is

Profluent is looking for a Scientist II - Sr. Scientist to develop and implement workflows for assessing the specificity and safety of their CRISPR base editing platform. The role involves establishing base-editor specificity workflows, collaborating with various teams to generate datasets, and mentoring junior scientists. The candidate will also be responsible for interpreting data, optimizing methods, and ensuring reproducibility in experimental processes.

Benefits
  • High-growth opportunity with meaningful impact on the future of protein design
  • Competitive compensation package with equity participation
  • 401(k) with a strong employer match
  • Comprehensive benefits including health/dental/vision insurance
  • Generous PTO policy and commitment to work-life balance
  • Professional development opportunities in a cutting-edge field at the intersection of AI and biology
Things to weigh
  • On-site position in Emeryville, California
  • No salary listed in the benefits section, but a hiring salary range is provided
  • Requires ongoing work authorization in the United States without employer sponsorship
Job score2.8/5
Benefits3/5
Freshness1/5
Career value5/5
Role clarity5/5
Pay transparency0/5

Applying to Profluent?

See how your résumé matches this role — and tailor it from what actually gets interviews.