HHiring Reality
← Profluent

Executive Director / Vice President, Biology & Translational Pharmacology

Profluent
Location
Emeryville, California, United States; On-site
Posted
2 months ago
Department
Biology
What they actually want (must-haves)
  • PhD, MD, DVM, PharmD, or equivalent advanced degree in pharmacology, molecular biology, genetics, physiology, hepatology, bioengineering, medicine, or a related discipline
  • 12+ years of biopharma R&D experience with a strong track record in genetic medicines, liver biology, translational pharmacology, and preclinical development
  • Demonstrated track record advancing multiple therapeutic programs from concept through development candidate nomination
  • Deep understanding of liver biology and metabolic disease
  • Experience designing and interpreting in vivo pharmacology studies
  • Demonstrated ability to lead multidisciplinary scientific teams
Nice to have
  • Direct experience with genome editing is valuable but not required
  • Experience advancing at least one program into IND-enabling studies or clinical development is strongly preferred
  • Extensive experience with rare liver diseases, lipid biology, hepatology, fibrosis biology, and/or metabolic liver disease
  • Working knowledge of IND-enabling requirements, toxicology interfaces, CMC considerations, bioanalytical assay needs, and regulatory expectations
  • Direct experience or at least high-level familiarity with gene editing proteins such as nucleases, base editors, prime editors, recombinases
What the job really is

Profluent is looking for an Executive Director / Vice President to lead the scientific strategy for their gene editing therapeutic portfolio, focusing on liver-directed customized base editing for severe inborn metabolic diseases. The role involves overseeing translational biology and in vivo pharmacology, managing cross-functional therapeutic programs, and collaborating with various teams to generate data packages for development candidates. The ideal candidate will have extensive experience in genetic medicines and a strong understanding of liver biology and metabolic diseases.

Benefits
  • High-growth opportunity with meaningful impact on the future of protein design
  • Competitive compensation package with equity participation
  • 401(k) with a strong employer match
  • Comprehensive benefits including health/dental/vision insurance
  • Generous PTO policy and commitment to work-life balance
  • Professional development opportunities in a cutting-edge field at the intersection of AI and biology
Things to weigh
  • No remote work options mentioned, position is on-site
  • High level of responsibility and leadership required
  • Candidates must have ongoing work authorization in the United States that does not require employer sponsorship
Job score2.8/5
Benefits3/5
Freshness1/5
Career value5/5
Role clarity5/5
Pay transparency0/5

Applying to Profluent?

See how your résumé matches this role — and tailor it from what actually gets interviews.

Calculate resume scoreGenerate resume to apply
Job Link →