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← NewLimit

Principal/Senior Scientist, mRNA engineering

NewLimit
Location
South San Francisco
Posted
2 months ago
Department
Technical Operations
Salary
$170,000 to $200,000
What they actually want (must-haves)
  • PhD in molecular biology, biochemistry, cell biology, or a related field, or equivalent industry experience (5+ years)
  • Hands-on experience optimizing IVT reactions and familiarity with scaling mRNA production (>10 mL scale)
  • Hands-on experience optimizing column chromatography purification steps (i.e., oligo-dT) on AKTA systems
  • Proficient in designing and executing UFDF/TFF steps
  • Experience managing external CDMOs, through process development and GMP manufacturing
  • Ability to perform and interpret basic mRNA analytical assays (Fragment Analyzer/TapeStation, restriction-digest + AGE, IP-RP-HPLC)
Nice to have
  • SME-level understanding of mRNA sequence design and manufacturability assessments
  • Experience with complex plasmid design, bacterial fermentation scale-up, and downstream purification for DNA template generation
  • Experience authoring regulatory submissions (IMPD-Q)
  • Experience managing or mentoring RAs/scientists, with interest in growing into a people-management role over time
What the job really is

The Principal/Senior Scientist will lead mRNA process development and engineering efforts at NewLimit, focusing on optimizing IVT yield and downstream purification for preclinical programs. This hands-on role involves managing tech transfer and scale-up activities at external CDMOs, collaborating with the analytical team, and building the mRNA Process Sciences team. The position requires staying updated on emerging mRNA techniques and establishing workflows for research-grade mRNA production.

Benefits
  • Health, dental, and vision insurance
  • 401(k) with company match
  • Paid parental leave
  • Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
  • Meals and snacks on-site
Things to weigh
  • No salary listed in the posting, only a range provided
  • The role involves building a new team, which may come with challenges
  • The position requires a hands-on approach, which may not suit all candidates
Job score3.4/5
Benefits3/5
Freshness1/5
Career value4/5
Role clarity4/5
Pay transparency5/5

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