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Principal Engineer, Lentivirus Downstream Process Development

Legend Biotech US
Location
Somerset, New Jersey, United States
Posted
26 days ago
Department
Process Analytical Development
What they actually want (must-haves)
  • Advanced degree (PhD preferred, or MS) in Chemical Engineering, Biomedical Engineering, bioprocessing engineering or a related field
  • 8+ years (PhD) or 10+ years (MS) of experience in process development or manufacturing within a biotech or pharmaceutical setting
  • Strong engineering knowledge of bioprocessing modeling/simulation and the interaction of biomolecules, materials and machinery
  • Experience with modeling software and programming languages such as Python and MATLAB
  • Deep technical experience in purification, chromatography, and TFF
  • Strong understanding of GMP manufacturing requirements and CMC strategies for early-phase and late phase clinical trials
Nice to have
  • Preferred experience in developing vector processes tailored for in vivo CAR-T generation and systemic delivery
  • Preferred experience in large scale (>50L) purification process
  • Language(s): Mandarin is a plus
What the job really is

The Principal Engineer in Lentivirus Downstream Process Development will lead the design, optimization, and scaling of purification processes for lentiviral vectors. This role involves applying engineering principles, data analytics, and advanced modeling to enhance process efficiency and ensure compliance with GMP manufacturing standards. The engineer will collaborate with various teams to translate bench-scale processes to GMP production and guide a team of scientists in project execution.

Benefits
  • Medical, dental, and vision insurance
  • 401(k) retirement plan with a company match that vests fully on day one
  • Eight (8) weeks of paid parental leave after just three (3) months of employment
  • Paid time off policy including vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays
  • Voluntary benefits including flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance
  • Voluntary commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs
Things to weigh
  • No salary listed in the posting, but a pay range is provided
  • Role involves significant responsibility and leadership, which may lead to high expectations
  • The position requires deep technical knowledge in a specialized field, which may limit candidates without specific experience
Job score3.4/5
Benefits3/5
Freshness4/5
Career value5/5
Role clarity5/5
Pay transparency0/5

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