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Scientist, AI/ML — Antibody Developability

Ginkgo Bioworks Inc.
Location
California, United States
Posted
18 days ago
Department
Datapoints Antibody Developability
Salary
$130,600 – $183,800
What they actually want (must-haves)
  • Ph.D. in Computational Biology, Bioinformatics, ML, Biophysics, or related quantitative field with emphasis on applied ML
  • Proficiency in Python and the scientific computing stack (NumPy, pandas, PyTorch/TensorFlow)
  • Demonstrated experience in supervised learning on biological datasets, including expertise in cross-validation and bias mitigation
  • Knowledge of protein representations, including PLM embeddings (e.g., ESM, AbLang) and structural featurization
  • Ability to analyze biophysical data with respect to signal-to-noise ratios and experimental dynamic range
  • Effective communication across multidisciplinary teams and ability to manage concurrent technical objectives
Nice to have
  • Familiarity with antibody formats (VHH, scFv), therapeutic developability liabilities, and relevant characterization assays
  • Experience with state of the art supervised techniques such as tabular foundation models
  • Exposure to generative sequence modeling, diffusion models, and reward-based steering
  • Experience with protein structure prediction (AlphaFold, ABodyBuilder) and surface patch analysis
  • Prior engagement with high-throughput experimental design and collaborative data generation
What the job really is

The Scientist, AI/ML — Antibody Developability role at Ginkgo Bioworks involves building and benchmarking machine learning models to predict and design antibody developability. The position requires collaboration with high-throughput biophysical platforms and the analysis of both customer and public datasets. Responsibilities include developing predictive models, implementing evaluation frameworks, and ensuring data integrity while disseminating findings through various scientific channels.

Benefits
  • Base salary range of $130,600 – $183,800
  • Company stock awards
  • Comprehensive benefits package including medical, dental & vision coverage
  • Health spending accounts
  • Voluntary benefits
  • Leave of absence policies
Things to weigh
  • Role is hybrid based in Boston, MA, with a return to office policy requiring in-office days 5x per week starting October 1, 2025
  • No specific mention of remote work flexibility for those outside the Boston area
  • Salary range provided but actual pay depends on skills and experience
  • Focus on a niche area of antibody developability may limit broader applicability of skills
Job score4.4/5
Benefits5/5
Freshness4/5
Career value4/5
Role clarity4/5
Pay transparency5/5

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