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Computational Synthetic Chemist

Ginkgo Bioworks Inc.
Location
Boston, Massachusetts
Posted
27 days ago
Department
Datapoints Small Molecule Developability
Salary
$115,000–$165,000
What they actually want (must-haves)
  • Ph.D. in synthetic organic chemistry, medicinal chemistry, or a closely related field plus 3 years of relevant industry or postdoctoral experience; or an M.S. with 6 years, or a B.S. with 9 years of relevant experience
  • Demonstrated ability to design and execute multi-step syntheses, including routes of approximately five or more steps through characterized final compounds
  • Independent route-design judgment under real constraints on materials, time, building blocks, and execution resources
  • Routine hands-on use of computer-aided synthesis planning or retrosynthesis tools
  • Fluency with chemical structure and reaction data, including molecular and reaction representations, compound registration, stereochemistry, salts, tautomers, and building-block catalogs
  • Experience with reaction screening, HTE, design of experiments, or related optimization workflows, plus disciplined structured capture of conditions, outcomes, analytical results, and failures
Nice to have
  • Python scripting with tools such as RDKit, pandas, or Jupyter
  • Experience running chemistry on robotic platforms, liquid handlers, flow systems, or other automated resources
  • Industrial HTE or nanoscale reaction-screening experience
  • Prior work in a CRO, fee-for-service, or similarly schedule-driven environment
  • Experience with ELN/LIMS configuration or reaction-data model definition
What the job really is

The Senior Engineer I, Computational Synthetic Chemist at Ginkgo Bioworks will design and execute multi-step syntheses of novel drug-like molecules. This role involves using computational tools for route planning and reaction prediction, while also mentoring junior chemists and collaborating with cross-functional teams. The position emphasizes practical application of synthetic chemistry in an automated laboratory environment.

Benefits
  • Competitive compensation
  • Generous equity in a public company
  • Comprehensive benefits package including medical, dental & vision coverage
  • Health spending accounts
  • Voluntary benefits
  • Leave of absence policies
Things to weigh
  • No mention of remote work flexibility; return to office policy requires in-office presence 5x per week for local employees
  • Role is heavily focused on practical chemistry rather than software or ML research, which may limit exposure to cutting-edge computational methods
  • The position requires balancing skepticism with practical progress, which may be challenging in a fast-paced environment
Job score4.6/5
Benefits5/5
Freshness4/5
Career value4/5
Role clarity5/5
Pay transparency5/5

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