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← Dyne Therapeutics

Principal Scientist, Oligonucleotide (PMO, ASO) Development

Dyne Therapeutics
Location
Waltham, MA
Posted
24 days ago
Department
1110GL - Technical Development
What they actually want (must-haves)
  • Bachelor’s degree in Biochemistry, Chemical Engineering, Chemistry, or Pharmaceutical Sciences
  • 8+ years of relevant pharmaceutical/biotech industry experience
  • Proven track record in the process chemistry and development of PMO and modified ASO oligonucleotides
  • Direct experience in the oversight of CDMOs
  • Technical proficiency in analytical development, including impurity control strategies
  • Exceptional interpersonal and communication skills
Nice to have
  • Advanced degree preferred
  • Experience in Research & Development preferably in a clinical-stage biotechnology company
What the job really is

The Principal Scientist of Oligonucleotide Development at Dyne Therapeutics will lead the strategy for chemical synthesis of PMO and modified ASO molecules, overseeing both internal execution and collaboration with CDMOs. This role involves driving process excellence, defining analytical strategies, and contributing to regulatory submissions while ensuring robust and scalable manufacturing processes. The position requires a strong presence on-site in Waltham, MA, 4-5 days a week.

Things to weigh
  • On-site presence required 4-5 days a week, no remote work option
  • Role involves significant regulatory responsibilities, which may be high-pressure
  • Salary range provided is broad and may vary based on individual qualifications
Job score2.8/5
Benefits1/5
Freshness4/5
Career value4/5
Role clarity5/5
Pay transparency0/5

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