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Principal Scientist, DMPK

Calico
Location
South San Francisco, CA
Posted
2 days ago
Department
DRUG DISCOVERY
Salary
$197,000 - $235,000
What they actually want (must-haves)
  • Ph.D. in pharmacokinetics, drug metabolism, or a related field
  • 8+ years of experience in DMPK within the pharmaceutical or biotechnology industry
  • Experience as a DMPK functional representative on drug discovery teams
  • Strong understanding of DMPK principles and their application to drug discovery and development
  • Extensive experience in designing and conducting in vitro and in vivo DMPK studies
  • Proven ability to analyze and interpret DMPK data to inform drug development decisions
Nice to have
  • Experience with a variety of therapeutic modalities, including small molecules, biologics, and peptides
  • Familiarity with regulatory guidelines and requirements for DMPK studies
  • Prior experience in writing regulatory documents is highly desirable
  • Experience with modeling and simulation software such as Phoenix WinNonlin, Gastroplus, SimCYP
What the job really is

The Principal Scientist, DMPK at Calico will lead the development and implementation of DMPK strategies to support drug discovery and development. This role involves collaborating with project teams and external partners, managing CRO relationships, and conducting DMPK studies. The scientist will also analyze data, author reports, and stay updated on advancements in DMPK science.

Benefits
  • Estimated base salary range of $197,000 - $235,000
  • Eligible for two annual cash bonuses
Things to weigh
  • Onsite work required 5 days a week
  • Role involves significant collaboration with external partners and CROs
  • Focus on DMPK may limit exposure to other areas of drug discovery
Job score4/5
Benefits1/5
Freshness5/5
Career value4/5
Role clarity5/5
Pay transparency5/5

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